A-10 Role of Fluid Cognitive Status in the Association of Frontoparietal Control and Cingulo-Opercular Networks with the Useful Field of View Task: Implications for Cognitive Training in Aging

Abstract Objective Training in a divided attention/speed-of-processing task called Useful Field of View (UFOV) reduced dementia risk older adults. Higher connectivity resting-state networks involved attention/inter-network modulation (cingulo-opercular network(CON); frontoparietal control network(FPCN)) relates to better UFOV performance. Cognitive status CON and Therefore, it may be an important third variable consider. This study assessed the mediation cognitive on relationship between CON/FPCN Methods 266 healthy adults (age M = 71.4, SD 5.18; 92% Caucasian) were recruited through clinical trial at University Florida Arizona. was defined by NIH Toolbox Fluid Composite score, assessing processing speed, attention/inhibition, executive functioning, working/episodic memory. via Double Decision assessment administered. Participants underwent functional magnetic resonance imaging. Average within-network FPCN extracted with CONN Toolboxv18b SPM12. Mediation performance controlling for sex, age, education, site. Results fully mediated indirect effect [b −0.1776; 95%CI (−0.3194, −0.0684)] Figure 1, −0.1461; (−0.2934, −0.0342)] 2. Conclusions accounted part association Older higher had stronger Future research should explore influence after training, investigate which domains are most influential.